Weight Loss Pills vs. Injections: Which Is Right for You?
Updated: November 11, 2024
Written by
Daniel Zvi
In the quest for effective weight loss solutions, both prescription weight loss pills and injectables have gained significant attention. Each offers unique benefits, but the choice between them often comes down to personal preferences, lifestyle, and specific health needs. This article delves into the key differences between weight loss pills and injections, focusing on convenience, effectiveness, side effects, and costs so you can make an informed decision about which option is best for you.
Our top picks for November 2024
Our top picks for November 2024
Our top picks for November 2024
9.9
9.9
Doctor Consultation
How Do Weight Loss Pills Work?
Prescription weight loss pills offer various mechanisms to help users lose weight. Let’s explore how the most commonly prescribed weight loss pills work and which types of individuals may benefit from them:Appetite Suppressants
Appetite suppressants work by targeting the brain’s hunger signals, making it easier for users to consume fewer calories. Medications like Phentermine® (Adipex-P®) and Qsymia® (a combination of Phentermine® and Topiramate) are popular for their ability to reduce cravings and control hunger. These pills are especially effective for individuals who struggle with overeating or constant hunger. Phentermine® has been a well-known option for many years due to its stimulant properties, which also increase energy levels, helping users feel more active while cutting down on calorie intake. A review published in Obesity Reviews showed that phentermine can be effective for short-term weight loss, helping individuals lose approximately 5-10% of their body weight over the course of a few months.Fat Absorption Blockers
Fat blockers like Orlistat® (sold under the brand names Xenical® and Alli®) prevent the absorption of dietary fat by inhibiting the enzyme lipase. By blocking this enzyme, about 30% of the dietary fat consumed passes through the body without being absorbed, thus lowering overall calorie intake. Orlistat® is a non-stimulant weight loss pill, making it a good option for those sensitive to stimulants or for people looking for a more gradual weight loss solution. It’s available both as a prescription and over-the-counter. A study published in Indian Journal of Endocrinology and Metabolism reported that Orlistat® users experienced a significant reduction in body weight in conjunction with lifestyle changes to achieve and maintain optimal weight.Craving and Emotional Eating Management
Contrave® (Naltrexone-Bupropion) is a combination of two medications designed to help reduce food cravings by influencing the brain’s reward system. This makes it particularly effective for individuals who struggle with emotional eating or eating in response to stress. Naltrexone, traditionally used to treat alcohol and opioid dependence, combined with Bupropion, an antidepressant, alters how the brain reacts to cravings, making it easier for users to stick to a calorie-controlled diet. Clinical studies published in The Lancet indicated that Contrave® helped users lose an average of 5-10% of their body weight over 56 weeks.
How Do Weight Loss Injections Work?
Weight loss injections primarily focus on mimicking natural hormones in the body that regulate appetite, insulin response, and digestion. These injectable medications—typically GLP-1 receptor agonists—are increasingly popular due to their effectiveness in helping people feel fuller for longer periods and reducing overall calorie intake.Popular Weight Loss Injections
- Wegovy® (Semaglutide)
- Ozempic® (Semaglutide, used off-label for weight loss, primarily prescribed for diabetes)
- Saxenda® (Liraglutide)
- Mounjaro® (Tirzepatide)
Pills vs. Injections: Key Differences
The method of administration is one of the most obvious differences between weight loss pills and injectables. Weight loss pills such as Phentermine® or Contrave® are taken daily, often before meals, making them a convenient option for those who prefer oral medication. In contrast, weight loss injections like Wegovy®, Ozempic®, and Mounjaro® are usually administered once a week, though Saxenda® is a daily injection. For individuals comfortable with needles, injectables may offer the benefit of less frequent dosing. For many people, the choice comes down to convenience and comfort. If you dislike the idea of daily medication, injectables with weekly dosing may be a better fit. However, those who prefer non-invasive methods might find pills more appealing.Treatment Effectiveness
While both pills and injections can be effective for weight loss, injectables tend to yield more significant results. Clinical trials suggest that GLP-1 receptor agonists, like Wegovy® and Mounjaro®, can lead to more substantial weight loss than pills alone. In a study published in JAMA, participants using Wegovy® experienced a 15-20% reduction in body weight over 68 weeks. Meanwhile, weight loss pills like Phentermine® or Contrave® typically lead to a 5-10% reduction in body weight over a year. While pills are still effective, injectables may be the better choice for individuals seeking faster or more substantial results.Side Effects
As with all medications, both weight loss pills and injections come with potential side effects.- Weight Loss Pills: Common side effects of appetite suppressants like Phentermine® include increased heart rate, dizziness, and insomnia. Fat blockers like Orlistat® can cause gastrointestinal issues such as oily stools, flatulence, and diarrhea. Contrave® may cause nausea, headaches, and constipation in some users.
- Weight Loss Injections: GLP-1 receptor agonists such as Wegovy® and Saxenda® may lead to gastrointestinal side effects, including nausea, vomiting, and diarrhea. However, these side effects often subside after a few weeks of use. Some individuals may also experience fatigue or mild discomfort at the injection site.
Long-Term Use
It’s important to note that while both weight loss pills and injections can provide short-term benefits, some options may be better suited for long-term use.- Phentermine® is typically prescribed for short-term use due to its stimulant properties and potential for dependence. However, medications like Qsymia® and Contrave® are often prescribed for longer-term use under medical supervision.
- GLP-1 agonists like Wegovy® and Saxenda® are generally safe for long-term use, particularly for individuals with obesity-related health conditions such as type 2 diabetes.
Who Should Consider Weight Loss Pills?
Weight loss pills are generally a good choice for individuals who:- Prefer oral medication over injections
- Seeking a less invasive treatment method
- Struggle with overeating or emotional eating
- Are seeking a more affordable option compared to injectables
Who Should Consider Weight Loss Injections?
Weight loss injections may be more suitable for individuals who:- Are comfortable with administering injections and prefer the convenience of once-weekly dosing (with medications like Wegovy® or Mounjaro®).
- Are looking for more significant, faster weight loss results.
- Have underlying conditions like type 2 diabetes, where GLP-1 receptor agonists provide additional benefits, such as improved blood sugar control.
Cost Comparison: Pills vs. Injections
Cost is a significant factor when choosing between weight loss pills and injections. Weight loss pills, such as Phentermine® and Orlistat®, tend to be more affordable. Qsymia®, for example, typically costs between $100 and $200 per month without insurance. Injectables, on the other hand, are generally more expensive. Wegovy® and Mounjaro® can cost $1,000 or more per month without insurance. Insurance coverage varies widely, and obtaining prior authorization may be necessary. For those paying out-of-pocket, the long-term financial commitment to injectables can be substantial, making pills a more budget-friendly option.Our top picks for November 2024
Making the Right Choice for Your Weight Loss Journey
Choosing between weight loss pills and injections depends on several factors, including your health goals, budget, and tolerance for medications. While injectables like Wegovy® and Mounjaro® may offer faster, more significant results, weight loss pills like Phentermine®, Contrave®, and Orlistat® are simpler and more accessible for many individuals. Consulting with your healthcare provider is essential to evaluate which option is best suited to your specific needs. Ultimately, both pills and injections offer valuable tools for weight loss, but the right choice will depend on your lifestyle, preferences, and long-term weight loss goals.Liked this article?
Daniel Zvi
Daniel Zvi writes articles on a plethora of different topics, from consumer goods to B2B tech software and everything in between. He has a B.A. in Communications, Marketing & Public Diplomacy. When he isn't writing or reading content he's probably cooking, eating or spending time with his friends and family.
Smart Recommendations
The above shall not be considered as medical, health or professional advice for any matter.
Thank you!